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Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets

Mbokou, Serge Foukmeniok and Pontié, Maxime and Bouchara, Jean-Philippe and Tchieno, Francis Merlin Melataguia and Njanja, Evangeline and Mogni, Assad and Pontalier, Pierre-Yves and Tonle, Ignas Kenfack Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets. (2016) International Journal of Electrochemistry, 2016. 1-10. ISSN 2090-3529

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Official URL: https://doi.org/10.1155/2016/1953278

Abstract

Electrochemical determination of acetaminophen (APAP) was successfully performed using a carbon paste electrode (CPE)modified with coffee husks (CH-CPE). Scanning electron microscopy (SEM) and SEM-energy dispersive X-ray spectroscopy (SEM-EDX) were, respectively, used for the morphological and elemental characterization of coffee husks prior to their utilization. Theelectrochemical oxidation of APAP was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and squarewave voltammetry (SWV). SWV technique appeared to be more sensitive since the oxidation current of APAP was twofold higherwith the CH-CPE sensor than with the bare CPE, in relation to the increase in the organophilic character of the electrode surface.Furthermore, on CH-CPE, the current response of APAP varied linearly with its concentration in the range of 6.6????M to 0.5 mM,leading to a detection limit of 0.66????M(????/????=3). Finally, the proposed CH-CPE sensor was successfully used to determine theamount of APAP in commercialized tablets (Doliprane�500 and Doliprane 1000), with a recovery rate ranging from 98% to 103%.This novel sensor opens the way for the development of low-cost and reliable devices for the electroanalysis of pharmaceuticalformulations in developing countries.

Item Type:Article
Additional Information:al. This is an open access article distributed under the Creative Commons
HAL Id:hal-02451825
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
Other partners > Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique - ONIRIS (FRANCE)
Other partners > University of Dschang (CAMEROON)
Other partners > Université de Nantes (FRANCE)
Other partners > IMT Atlantique Bretagne-Pays de la Loire - IMT Atlantique (FRANCE)
Other partners > Université Nantes Angers Le Mans - UNAM (FRANCE)
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Deposited On:23 Jan 2020 11:44

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