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Polymeric self-assemblies for photodynamic therapy: A critical approach

Till, Ugo and Gibot, Laure and Mingotaud, Anne-Françoise and Mingotaud, Christophe and Rols, Marie-Pierre and Gaucher, Mireille and Violleau, Frédéric and Vicendo, Patricia Polymeric self-assemblies for photodynamic therapy: A critical approach. (2017) Photodiagnosis and Photodynamic Therapy, 17. A23-A24. ISSN 1572-1000

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Official URL: https://doi.org/10.1016/j.pdpdt.2017.01.053


The work presented here suggests a new approach in the critical development of polymeric nanovectors for photodynamic therapy (PDT) against cancer. Whereas hundreds of studies quickly jump forward from formation of self-assemblies to biological application without having a thorough examination of the vector solution, we suggest having a parallel assessment of formation/characterization of the nanovectors and biological activity [1]. This is possible by first using a careful physical chemistry characterization of the vectors by both batch techniques (light and neutron scattering, electron microscopy, atomic force microscopy) and Asymmetrical Flow Field-Flow Fractionation (AsFlFFF) coupled to adequate detectors (refractometry, light scattering) [2]. This enables us to fully characterize the vectors regarding purity, size and zeta potential.

Item Type:Article
HAL Id:hal-03511855
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Ecole d'Ingénieurs de Purpan - EIP (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Deposited On:27 Nov 2019 09:26

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