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Influence of the culture conditions on the production of NGPs by Aspergillus tubingensis

Leon, Lilia Lopez de and Caceres, Isaura and Bornot, Julie and Choque, Elodie and Raynal, José and Taillandier, Patricia and Mathieu, Florence Influence of the culture conditions on the production of NGPs by Aspergillus tubingensis. (2019) Journal of Microbiology and Biotechnology, 29 (9). 1412-1423. ISSN 1017-7825

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Official URL: https://doi.org/10.4014/jmb.1905.05015


The filamentous fungus Aspergillus tubingensis that belongs to the black Aspergillus section has the capacity to produce high-value metabolites, for instance, Naphtho-Gamma-Pyrones (NGPs). For these fungal secondary metabolites, numerous biological properties of industrial interest have been demonstrated, such as antimicrobial, antioxidant and anti-cancer capacities. It has been observed that these secondary metabolites production is linked with the fungal sporulation. The aim of this research was to apply environmental stresses to trigger the production of NGPs in liquid cultures with CYB (Czapek Dox Broth): osmotic and oxidative stresses. In addition, numerous parameters were tested during the experiments, such as pH value, incubation time, container geometry, and static and agitation conditions. Results demonstrate that the produced amount of NGPs can be enhanced by decreasing the water activity (aw) or by adding an oxidative stress factor. In conclusion, this study can contribute to our knowledge regarding A. tubingensis to present an effective method to increase NGPs's production, which may support the development of current industrial processes.

Item Type:Article
HAL Id:hal-02366263
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Deposited On:15 Nov 2019 16:59

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