OATAO - Open Archive Toulouse Archive Ouverte Open Access Week

Paracetamol Sensitive Cellulose-Based Electrochemical Sensors

Pontié, Maxime and Mbokou, Serge Foukmeniok and Bouchara, Jean-Philippe and Razafimandimby, Bienvenue and Egloff, Sylvie and Dzilingomo, Ornella and Pontalier, Pierre-Yves and Tonle, Ignas Kenfack Paracetamol Sensitive Cellulose-Based Electrochemical Sensors. (2018) Journal of Renewable Materials, 6 (3). 242-250. ISSN 2164-6325

(Document in English)

PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader

Official URL: https://doi.org/10.7569/JRM.2017.634169


Electrochemical determination of paracetamol (PCT) was successfully performed using carbon paste electrodes (CPEs) modified with treated coffee husks (CHt) or cellulose powder (Ce). Scanning electron microscopy was used to characterize unmodified or modified CPEs prior to their use. The electrochemical oxidation of PCT was investigated using square wave voltammetry (SWV) and cyclic voltammetry (CV). The oxidation current density of PCT was two-fold higher with the CPE-CHt sensor and 30% higher with CPE-Ce in comparison with the unmodified CPE, and this correlated with the higher hydrophilicity of the modified electrodes. Using SWV for the electrochemical analysis of PCT, carbon paste electrode modified with raw coffee husks (CPE-CHr) showed the presence of impurities at +0.27 V/SCE, showing the interest in using pure cellulose for the present analytical application. Furthermore, CPE-Ce presented a higher real area compared to CPE-CHr, which explains the increase in the limit of saturation from 400 mg/L to 950 mg/L. The better saturation limit exhibited by CPE-Ce justifies its choice for electroanalysis of PCT in commercialized tablets. The proposed method was successfully applied in the determination of PCT in commercialized tablets (Doliprane® 500) with a recovery rate close to 100%, and no interference with the excipients contained in the tablets analyzed was observed.

Item Type:Article
HAL Id:hal-02375921
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
Other partners > University of Dschang (CAMEROON)
Other partners > Université Nantes Angers Le Mans - UNAM (FRANCE)
Other partners > Université Bretagne Loire (FRANCE)
Laboratory name:
Deposited On:22 Nov 2019 10:50

Repository Staff Only: item control page