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Effect of methylene blue on the formation of oxidized phospholipid vesicles

Fabre, Jean-François and Cerny, Muriel and Cassen, Audrey and Mouloungui, Zéphirin Effect of methylene blue on the formation of oxidized phospholipid vesicles. (2018) bioRxiv. 1-32. ISSN 2692-8205

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Official URL: https://doi.org/10.1101/403634


Soybean phosphatidylcholine, which is rich in linoleic acid, was oxidized with singlet oxygen through photosensitization with methylene blue. This compound facilitates the oxidation of phospholipids relative to the reaction with free unsaturated fatty acids. A response surface methodology was used to control oxidation, with methylene blue concentration and the amount of available air as independent variables. The conjugated diene-to triene ratio was then monitored. Hydroperoxide yield dependent principally on the amount of air, whereas photosensitizer concentration strongly influenced the size and zeta potential of vesicles formed by the sonication of oxidized phospholipids in water. Methylene blue plays an important role in the surface charge expression and ion permeability of these vesicles.

Item Type:Article
Additional Information:CC-BY-NC-ND 4.0 International license
HAL Id:hal-03037371
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
Laboratory name:
Occitanie region
Deposited On:05 Nov 2019 16:25

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