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Nanocrystalline apatites: synthesis, physical-chemical and thermodynamic characterization

Iafisco, Michele and Delgado-López, José Manuel and Drouet, Christophe Nanocrystalline apatites: synthesis, physical-chemical and thermodynamic characterization. (2014) In: Apatite : Synthesis, Structural Characterization and Biomedical Applications. (Geology and Mineralogy Research Developments). Nova Science Publishers, New York, 49-80. ISBN 978-1-63321-500-9

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Abstract

Nanocrystalline nonstoichiometric apatites constitute the mineral part of bones, and synthetic approacheshave been developed to prepare “biomimetic analogs” via “soft” chemical routes. Thesecompounds exhibit many differences to stoichiometric hydroxyapatite, in that they are nanocrystalline, hydrated, nonstoichiometric, plate-like shaped, and thermodynamically metastable. All these features can in fact explain the many peculiarities of their physical-chemical (and thus biological) properties as well as their ability to evolve spontaneously in solution. After reviewing the occurrence of apatite nanocrystals in vivo, we present in this contribution the main synthesis routes to prepare biomimetic analogs, and we then address some of the latest developments in physical-chemical and thermodynamic characterization of nanocrystalline apatites, focusing on advanced total scattering, vibrational spectroscopies, and calorimetry techniques. As in bone, apatite nanocrystals exhibit a very peculiar surface state that includes highly-labile ions confined in an ionic and hydrated metastable layer on the surface of the nanocrystals. These labile ions then take part to surface ion exchanges and adsorption mechanisms relevant for their biological activity.

Item Type:Book Section
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Consiglio Nazionale delle Ricerche - CNR (ITALY)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Universidad de Granada - UGR (SPAIN)
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Deposited On:28 Oct 2019 13:17

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