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Influence of Homogenization Technique and Blend Ratio on Chitosan/Alginate Polyelectrolyte Complex Properties

Castel, Marion and Conzatti, Guillaume and Torrisani, Jérôme and Rouilly, Antoine and Cavalie, Sandrine and Carrere, Nicolas and Tourrette, Audrey Influence of Homogenization Technique and Blend Ratio on Chitosan/Alginate Polyelectrolyte Complex Properties. (2018) Journal of Medical and Biological Engineering, 38 (1). 10-21. ISSN 1609-0985

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Official URL: https://doi.org/10.1007/s40846-017-0304-7

Abstract

Polyelectrolyte complex (PEC) films were prepared from chitosan (CHI) and alginate (ALG) which are polymers of opposite charge. Two homogenization techniques and two ratios of ALG–CHI blends were compared: mechanical agitation under vacuum (ALG–CHI ST) or agitation by high turbulence (ALG–CHI UT) and 50/50 or 63/37 ratios. Surface and structure of PEC films are affected by the homogenization technique while the swelling percentage is only affected by polymer ratio. The homogenization ratio does not seem to influence in vitro cell proliferation. Results show that the UT homogenization technique with a 63/37 ratio, which gives films with a smooth, homogeneous surface and a higher rate of enzymatic resistance, is more efficient for cell proliferation and viability. These first results confirm the potential use of ALG–CHI films for surgery application.

Item Type:Article
HAL Id:hal-02336123
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
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Agence Nationale de la Recherche - ANR
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Deposited On:28 Oct 2019 15:31

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