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Foam-Based Bionanocomposite Scaffold for Bone Tissue Engineering

Quemeneur, Fany and Tourne-Peteilh, Corine and Drouet, Christophe and Dupret Bories, Agnès and Tourrette, Audrey and Begu, Sylvie and Girod-Fullana, Sophie Foam-Based Bionanocomposite Scaffold for Bone Tissue Engineering. (2017) Key Engineering Materials, 758. 145-149. ISSN 1662-9795

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Official URL: https://doi.org/10.4028/www.scientific.net/KEM.758.145

Abstract

The repair of large bone defects is a major clinical problem for which tissue engineering (association of a biomaterial and cells) constitutes a valuable alternative. In this domain, the architecture and the mechanical properties of the 3D scaffold aimed to support cells is of key importance to succeed in bone reconstruction. In this study, we aim to design and evaluate a bionanocomposite foam-based scaffold, exhibiting all the desired biofunctional attributes of biocompatibility, bioactivity, osteoconduction/induction, combined with potential release properties. To perform this, 2 components have been associated: (i) a biopolymer, pectin, incorporating (ii) calcium phosphate nanoparticules to provide bone apatite nucleation sites, mechanical reinforcement, and to play the role of potential drug reservoir. The goal of this study was to determine the feasibility of obtention of such bionanocomposite by foam-templating, and to study the influence of mineral particules ratio on pectin foam and final scaffold 3D architecture and properties.

Item Type:Article
HAL Id:hal-01743571
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Ecole Nationale Supérieure de Chimie de Montpellier - ENSCM (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Université de Montpellier (FRANCE)
Laboratory name:
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Deposited By: Yves MOMBOISSE
Deposited On:09 Dec 2019 12:55

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