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Biocompatibility of a new biodegradable polymer-hydroxyapatite composite for biomedical applications

Macha, Innocent Jacob and Ben-Nissan, Besim and Santos, Jerran and Cazalbou, Sophie and Stamboulis, Artemis and Grossin, David and Giordano, Gerard Biocompatibility of a new biodegradable polymer-hydroxyapatite composite for biomedical applications. (2017) Journal of Drug Delivery Science and Technology, 38. 72-77. ISSN 1773-2247

(Document in English)

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Official URL: https://doi.org/10.1016/j.jddst.2017.01.008


The rise in the number of musculoskeletal disorders (MSDs) due to an increasingly aging population has led to a growing demand for medication to prevent and treat these diseases. An increased interest in the development of new drugs to allow treatment of these diseases in their very early stages is currently observed. The current approach on local direct delivery of medication and key minerals to support bone repair and regeneration at the defect site, from flexible degradable devices, seems to be an effective strategy. Polylactic acid (PLA) and microspheres of hydrothermally converted coralline hydroxyapatite (cHAp) were used to develop PLA thin film composites as drug delivery systems. The PLA provided flexibility and biodegradability of the systems, while coralline hydroxyapatite provided the required calcium and phosphate ions for bone regeneration. These coralline hydroxyapatite microspheres have a unique architecture of interconnected porosity, are bioactive in nature and suitable for drug loading and controlled slow drug release. The cell attachment and morphology of the PLA thin film composites were evaluated in vitro using cell cultures of human adipose derived stem cells (hADSC). It was shown that hADSC cells exhibited a strong attachment and proliferation on PLA thin film-cHAp composites, signifying high biocompatibility and a potential for osteointegration due to the presence of HAp.

Item Type:Article
HAL Id:hal-02402578
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Contact Orthopedie (FRANCE)
Other partners > Hôpital Joseph Ducuing (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Other partners > University of Dar es Salaam (TANZANIA)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > University of Technology, Sydney - UTS (AUSTRALIA)
Other partners > University of Birmingham (UNITED KINGDOM)
Laboratory name:
European Union's Horizon 2020 research and innovation programme - Australian Academy of Science
Deposited On:10 Dec 2019 14:09

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