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Alginate/chitosan polyelectrolyte complexes: A comparative study of the influence of the drying step on physicochemical properties

Conzatti, Guillaume and Faucon, Déborah and Castel, Marion and Ayadi, Farouk and Cavalie, Sandrine and Tourrette, Audrey Alginate/chitosan polyelectrolyte complexes: A comparative study of the influence of the drying step on physicochemical properties. (2017) Carbohydrate Polymers, 172. 142-151. ISSN 0144-8617

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Official URL: https://doi.org/10.1016/j.carbpol.2017.05.023

Abstract

Polyelectrolyte complexes (PECs) based on Alginate and Chitosan were prepared for biomedical application. These two biopolymers are valuable resources for biomedical applications. In the present work, three PECs materials were produced using three different drying techniques: hot air drying, lyophilization and supercritical CO2 drying. The choice of the drying technique allowed producing different type of structures, with different porosity scale. In order to evaluate their potential as intra-abdominal wound dressings, swelling ability in various media, enzymatic resistance and drug release behavior of the resulting materials was studied. It was shown that the increase of the porosity improved the swelling ability, without altering the resistance of the materials, whereas drug release studies revealed that the majority of the drug was released within the first 24h whatever the drying process.

Item Type:Article
HAL Id:hal-02390713
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Laboratory name:
Funders:
National Agency for Research and Technology - ANRT
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Deposited By: Yves MOMBOISSE
Deposited On:03 Dec 2019 10:31

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