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In vitro bioactivity and stem cells attachment of three-dimensionally ordered macroporous bioactive glass incorporating iron oxides

Charoensuk, Thanida and Sirisathitkul, Chitnarong and Boonyang, Upsorn and Macha, Innocent Jacob and Santos, Jerran and Grossin, David and Ben-Nissan, Besim In vitro bioactivity and stem cells attachment of three-dimensionally ordered macroporous bioactive glass incorporating iron oxides. (2016) Journal of Non-Crystalline Solids, 452. 62-73. ISSN 0022-3093

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Official URL: https://doi.org/10.1016/j.jnoncrysol.2016.08.019

Abstract

Three-dimensionally ordered macroporous bioactive SiO2-CaO-Na2O-P2O5 glass (3DOM-BG) is synthesized by using the sol-gel method. After an in vitro test in simulated body fluid (SBF), the hydroxyapatite (HAp) crystalline phase is clearly formed on its surface as confirmed by X-ray diffractometry (XRD) and Raman spectroscopy. Magnetic 3DOM-BG/Fe samples are synthesized by partial substitution of SiO2 with iron oxide. Whilst the HAp layer is not confirmed, energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR) and XRD analysis reveal calcium phosphate layer on the surface of 3DOM-BG/Fe samples after the SBF soaking. The growth of HAp-like layer is slower with increasing iron oxides. The initial mechanism that thought to induce bone formation is reduced due to the replacement of Ca2+ with Fe ions in the glass network. The formation of HAp-like layer is modified by the sedimentation of Ca and P while the nonmagnetic 3DOM-BG forms the calcium phosphate by the ionic exchange following the Hench mechanism. The adult human adipose tissue-derived stem cells (hADSCs) can be closely attached and well spread on the flat-plate of all 3DOM-BG/Fe and 3DOM-BG. Without detectable cytotoxicity possibly induced by iron oxides, the osteoblast can be grown and proliferated. In addition to these bioactivity and biocompatibility, porous structures can allow their possible use in targeted drug delivery and magnetic properties of 3DOM-BG/Fe can essentially be implemented in hyperthermia therapy.

Item Type:Article
HAL Id:hal-02419313
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > University of Technology, Sydney - UTS (AUSTRALIA)
Other partners > Walailak University - WU (THAILAND)
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Deposited On:19 Dec 2019 12:52

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