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Self-Cleaning Interfaces of Polydimethylsiloxane Grafted with pH-Responsive Zwitterionic Copolymers

De Vera, Jacqueline S. and Venault, Antoine and Chou, Ying-Nien and Tayo, Lemmuel and Chiang, Heng-Chieh and Aimar, Pierre and Chang, Yung Self-Cleaning Interfaces of Polydimethylsiloxane Grafted with pH-Responsive Zwitterionic Copolymers. (2019) Langmuir, 35 (5). 1357-1368. ISSN 0743-7463

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Official URL: https://doi.org/10.1021/acs.langmuir.8b01569

Abstract

Self-cleaning surfaces allow the reversible attachment and detachment of microorganisms which show great promise in regards to their reusability as smart biomaterials. However, a widely used biomaterial such as polydimethylsiloxane (PDMS) suffers from high biofouling activity and hydrophobic recovery that results in decreased efficiency and stability. A current challenge is to modify and fabricate self-cleaning PDMS surfaces by incorporating antifouling and pH-sensitive properties. To address this, we synthesized a zwitterionic and pH-sensitive random poly(glycidyl methacrylate-co-sulfobetaine methacrylate-co-2-(dimethylamino)ethyl methacrylate) polymer, poly(GMA-co-SBMA-co-DMAEMA). In this work, chemical modification of PDMS was done by grafting onto poly(GMA-co-SBMA-co-DMAEMA) after surface activation via UV and ozone for 90 min to ensure the formation of covalent bonds necessary for stable grafting. The PDMS grafted with G20-S40-D40 exhibit antifouling and pH-sensitive properties by mitigating fibrinogen adsorption, blood cell adhesion, and releasing 98% adhered E. coli bacteria after immersion at basic pH. The grafting of poly(GMA-co-SBMA-co-DMAEMA) presented in this work shows attractive potential for biomedical and industrial applications as a simple, smart, and effective method for the modification of PDMS interfaces.

Item Type:Article
HAL Id:hal-02305398
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Changhua Christian Hospital (TAIWAN)
Other partners > Chung Yuan Christian University - CYCU (TAIWAN)
Other partners > Mapúa University (PHILIPPINES)
Laboratory name:
Funders:
Agence Nationale de la Recherche - ANR (FRANCE)
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Deposited On:23 Sep 2019 12:36

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