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Single-step pulsed electrodeposition of calcium phosphate coatings on titanium for drug delivery

Vidal, Elia and Buxadera-Palomero, Judit and Pierre, Camille and Manero, José M and Ginebra, Maria-Pau and Cazalbou, Sophie and Combes, Christèle and Ruperez, Elisa and Rodriguez, Daniel Single-step pulsed electrodeposition of calcium phosphate coatings on titanium for drug delivery. (2019) Surface and Coatings Technology, 358. 266-275. ISSN 0257-8972

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Official URL: https://doi.org/10.1016/j.surfcoat.2018.11.037

Abstract

Metallic implants have some limitations related to bioactivity and bacteria colonization leading to infections. In this regard, calcium phosphate coatings can be used as carrier for drug delivery in order to improve the mentioned drawbacks. The present work proposes the introduction of an antibacterial agent in the course of a pulsed and reverse pulsed electrodeposition. Calcium phosphate coatings were prepared in 30min using different pulse waveforms (unipolar-bipolar), current densities (2–5mA/cm2) and temperatures (40–60°C). Mechanical stability of the as-coated surfaces was studied in order to select the optimal electrodeposition conditions. Subsequently, selected coatings were loaded with an antiseptic agent, chlorhexidine digluconate (CHX), via a single-step co-deposition procedure. CHX concentration added to the electrolyte was adjusted to 3mM based on the antibacterial efficacy of the loaded coatings evaluated in vitro with Staphylococcus aureus and Escherichia coli bacteria strains. Whereasthe same chlorhexidineconcentration was addedto the electrolyte, results showedthat the amount of CHX loaded was different for each condition while release kinetics was maintained. The results of this work demonstrate that a pulsed co-deposition strategy has great potential to modulate local delivery of antibacterial agents such as chlorhexidine digluconate, which may prevent early phase infections of metallic implants after insertion.

Item Type:Article
HAL Id:hal-02278318
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Universitat Politècnica de Catalunya - UPC (SPAIN)
Laboratory name:
Funders:
EU Cost action Ipromedai, Catalan Agency for Management of University and Research Grants,Région Midi Pyrénées - Catalan Agency for Management of University and Research Grants
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Deposited On:04 Sep 2019 10:10

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