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A new formulation for blood substitues

Cecutti, Marie-Christine and Novelli, Anne and Rico-Lattès, Isabelle and Lattes, Armand A new formulation for blood substitues. (2007) Journal of Dispersion Science and Technology, 11 (2). 115-123. ISSN 0193-2691

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Official URL: https://doi.org/10.1080/01932699008943243

Abstract

The synthesis of a novel microemulsion system composed of a fluorinated oil C8F17-CH2-CH-CH-C4H9 with a biocompatible hy-drogenated surfactant, Montanox 80, is described. Investigation of the solubility of oxygen in these microe-mulsions showed that they absorbed more oxygen than Fluosol-DA, currently used as an oxygen transporter in biological systems. Oxygen absorption was comparable to that of blood. Light scattering studies showed that these systems are composed of small-sized aggregates which should, in principle, be compatible with blood. The toxicity of the oil C8F17-CH2-CH = CH-C4H9 was tested after intraperitoneal injection in rats. No toxic effects were observed at doses up to 5 g/kg This study opens new perspectives for the development of oxygen-transporting compounds for biomedical applications.

Item Type:Article
HAL Id:hal-02168142
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
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Deposited By: Yves MOMBOISSE
Deposited On:28 Jun 2019 12:16

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