Cecutti, Marie-Christine
and Novelli, Anne and Rico-Lattès, Isabelle and Lattes, Armand
A new formulation for blood substitues.
(2007)
Journal of Dispersion Science and Technology, 11 (2). 115-123. ISSN 0193-2691
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(Document in English)
PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 1MB |
Official URL: https://doi.org/10.1080/01932699008943243
Abstract
The synthesis of a novel microemulsion system composed of a fluorinated oil C8F17-CH2-CH-CH-C4H9 with a biocompatible hy-drogenated surfactant, Montanox 80, is described. Investigation of the solubility of oxygen in these microe-mulsions showed that they absorbed more oxygen than Fluosol-DA, currently used as an oxygen transporter in biological systems. Oxygen absorption was comparable to that of blood. Light scattering studies showed that these systems are composed of small-sized aggregates which should, in principle, be compatible with blood. The toxicity of the oil C8F17-CH2-CH = CH-C4H9 was tested after intraperitoneal injection in rats. No toxic effects were observed at doses up to 5 g/kg This study opens new perspectives for the development of oxygen-transporting compounds for biomedical applications.
| Item Type: | Article |
|---|---|
| HAL Id: | hal-02168142 |
| Audience (journal): | International peer-reviewed journal |
| Uncontrolled Keywords: | |
| Institution: | Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE) French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE) |
| Laboratory name: | |
| Statistics: | download |
| Deposited On: | 28 Jun 2019 12:16 |
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