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New formulation of blood substitutes: optimization of novel fluorinated microemulsions

Cecutti, Marie-Christine and Rico-Lattès, Isabelle and Lattes, Armand and Novelli, Anne and Rico, André and Marion, Gérard and Graciaa, Alain and Lachaise, Jean New formulation of blood substitutes: optimization of novel fluorinated microemulsions. (1989) European Journal of Medicinal Chemistry, 24 (5). 485-492. ISSN 0223-5234

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Official URL: https://doi.org/10.1016/0223-5234(89)90052-4


The synthesis of a novel microemulsion system composed of a mixed fluorinated and hydrogenated oil C8F17CH2CHCHC4H9 with a biocompatible hydrogenated surfactant, Montanox 80 is described. Investigation of the solubility of oxygen in these microemulsions showed that they absorbed more oxygen than Fluosol-DA which is currently used as an oxygen transporter in biomedical applications. Oxygen absorption was similar to that of blood. Light scattering studies showed that the system was composed of small sized aggregates which should in principle be compatible with blood. The toxicity of the microemulsions was tested after intraperitoneal injection in rats, and in mice after intravenous administration. The microemulsions appeared to be well tolerated. These results show promise for the development of oxygen transporting compounds.

Item Type:Article
HAL Id:hal-02094811
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Université de Pau et des Pays de l'Adour - UPPA (FRANCE)
Laboratory name:
Deposited On:10 Apr 2019 06:18

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