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Surface enrichment of biomimetic apatites with biologically-active ions Mg2+ and Sr2+: A preamble to the activation of bone repair materials

Drouet, Christophe and Carayon, Marie-Thérèse and Combes, Christèle and Rey, Christian Surface enrichment of biomimetic apatites with biologically-active ions Mg2+ and Sr2+: A preamble to the activation of bone repair materials. (2008) Materials Science and Engineering C, 28 (8). 1544-1550. ISSN 0928-4931

(Document in English)

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Official URL: http://dx.doi.org/10.1016/j.msec.2008.04.011


The surface activation of calcium phosphate-based biomaterials for bone repair is an emerging route for improving bone regeneration processes. One way for such activation is through the exchange of surface calcium ions with biologically-active cations such as Mg2+ or Sr2+. In this work, the interactions of noncarbonated and carbonated nanocrystalline apatites with Mg2+ and Sr2+ were investigated by means of ion exchange experiments in solution. Langmuir-type isotherms were determined. For both Sr and Mg, a greater uptake was observed on the carbonated sample, and on both types of apatites the maximum strontium uptake was greater than that of magnesium. Inverse exchanges showed that the proportion of reversibly fixed ions after surface exchange was close to 85% for Mg and 75–80% for Sr. The results are related to the presence of a surface hydrated layer on the nanocrystals and possible exchange mechanisms are discussed. Our results favor the hypothesis of hetero-ionic surface exchanges (Mg2+↔Ca2+, Sr2+↔Ca2+) within the hydrated layer, and some analogy with octacalcium phosphate (OCP) is considered. This work should prove helpful for the control and understanding of the activation of synthetic apatite-based powders or scaffolds with bioactive elements, as well as for the global understanding of biomineralization processes.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at Materials Science and Engineering C website : http://www.sciencedirect.com/science/journal/09284931
HAL Id:hal-03590700
Audience (journal):International peer-reviewed journal
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Institution:Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
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Deposited On:20 Apr 2009 12:28

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