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Antioxidant activity of phenolic acids and esters present in red wine on human Low-Density Lipoproteins

Urizzi, Pascale and Monje, Marie-Carmen and Souchard, Jean-Pierre and Abella, Annie and Chalas, Jacqueline and Lindenbaum, Albert and Vergnes, Laurent and Labidalle, Serge and Nepveu, Françoise Antioxidant activity of phenolic acids and esters present in red wine on human Low-Density Lipoproteins. (1999) Journal de Chimie Physique et de Physico-Chimie Biologique, 96 (1). 110-115. ISSN 0021-7689

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Official URL: https://doi.org/10.1051/jcp:1999117


To evaluate the antioxidant activity of different phenolic acids and their esters, three types of experiments have been used. Electron paramagnetic resonance (EPR) quantitative analysis was carried out using the acetaldehyde/xanthine oxidase system and Fenton's reaction to generate superoxide and hydroxyl radicals, respectively. In a second test, hydroperoxides generated by Cu2+-catalysed oxidation of low density lipoproteins (LDL) were quantified by a modified iodometric method. In a third assay, LDL were oxidized with Esterbauer's method and modified LDL species were quantified by HPLC. The results show that the esterified phenolic derivatives present a better antioxidant activity, on the lipoperoxidation of LDL, than the corresponding phenolic acids.

Item Type:Article
HAL Id:hal-02143187
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Assistance publique - Hôpitaux de Paris - AP-HP (FRANCE)
Deposited On:07 Mar 2019 07:57

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