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Polyphenols as superoxide dismutase modulators and ligands for estrogen receptors

Farines, Vincent and Monje, Marie-Carmen and Telo, Joao Paulo and Hnawia, Edouard and Sauvain, Michel and Nepveu, Françoise Polyphenols as superoxide dismutase modulators and ligands for estrogen receptors. (2004) Analytica Chimica Acta, 513 (1). 103-111. ISSN 0003-2670

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Official URL: https://doi.org/10.1016/j.aca.2003.08.065


The capacity of estrogen and stilbene derivatives to modulate the activity of superoxide dismutases in relation with their estrogenic properties has been studied. The properties of trans-resveratrol (3,5,4′-trihydroxystilbene) and its analogues, 4-hydroxystilbene, 4,4′-dihydroxystilbene, 3,5-dihydroxystilbene, 3,5,4′-trimethoxystilbene and 4,4′-dihydroxy-3,5,3′,5′-tetramethylstilbene were compared to 17β-estradiol and its analogues (2-methoxyestradiol, estrone, 2-hydroxyestradiol and 2-methoxyestrone). Measurement of estrogen receptor-β (ER-β) binding capacity was carried out by a receptor competitor assay associated with fluorescence polarisation detection. The superoxide dismutase (SOD) modulation activity was followed with a spectrophotometric assay using the sequence xanthine/xanthine oxidase-2,3-bis[2-methoxy-4-nitro-sulfo-phenyl]-2H-tetrazolium-5-carboxanilide (X/XO-XTT). The structure–activity relationship was different for the two series tested. In the estrogenic series, a compound which does not inhibit SOD, is recognized by the ER-β. In contrast for the stilbenic series both properties are parallel each other.

Item Type:Article
HAL Id:hal-02134662
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Institut de Recherche pour le Développement - IRD (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Instituto Superior Técnico (PORTUGAL)
Other partners > Université de la Nouvelle Calédonie - UNC (FRANCE)
Laboratory name:
Conseil Régional Midi-Pyrénées - (FRANCE) - Association “Société de Secours des Amis des Sciences” - (FRANCE)
Deposited On:04 Apr 2019 08:40

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