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Blood schizontocidal activity of methylene blue in combination with antimalarials againstPlasmodium falciparum

Garavito, Giovanny and Bertani, Stephane and Rincon, Javier and Maurel, Séverine and Monje, Marie-Carmen and Landau, Irene and Valentin, Alexis and Deharo, Eric Blood schizontocidal activity of methylene blue in combination with antimalarials againstPlasmodium falciparum. (2007) Parasite, 14 (2). 135-140. ISSN 1776-1042

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Official URL: https://doi.org/10.1051/parasite/2007142135

Abstract

Methylene blue (MB) is the oldest synthetic antimalarial. It is not used anymore as antimalarial but should be reconsidered. For this purpose we have measured its impact on both chloroquine sensitive and resistant Plasmodium strains. We showed that around 5 nM of MB were able to inhibit 50% of the parasite growth in vitro and that late rings and early trophozoites were the most sensitive stages; while early rings, late trophozoites and schizonts were less sensitive. Drug interaction study following fractional inhibitory concentrations (FIC) method showed antagonism with amodiaquine, atovaquone, doxycycline, pyrimethamine; additivity with artemether, chloroquine, mefloquine, primaquine and synergy with quinine. These results confirmed the interest of MB that could be integrated in a new low cost antimalarial combination therapy.

Item Type:Article
HAL Id:hal-02143176
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Institut de Recherche pour le Développement - IRD (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Museum National d'Histoire Naturelle - MNHN (FRANCE)
Other partners > Universidad Nacional de Colombia (COLOMBIA)
Laboratory name:
Funders:
European Union - Pierre & Marie Curie University, Paris 6 - Ministère délégué à la Recherche
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Deposited By: Loetitia MOYA
Deposited On:07 Mar 2019 13:02

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