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Impact of Calcium Phosphate Particle Morphology on Osteoconduction: an in vivo study

Drouet, Christophe and Barré, Ronan and Brunel, Gérard and Dechambre, Gérard and Benqué, Edmond and Combes, Christèle and Rey, Christian Impact of Calcium Phosphate Particle Morphology on Osteoconduction: an in vivo study. (2008) Key Engineering Materials, 361 - 3. 1237-1240. ISSN 1013-9826

(Document in English)

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Official URL: http://dx.doi.org/10.4028/www.scientific.net/KEM.361-363.1237


Apatite/β−TCP particles exhibiting non-conventional urchin-like morphology were prepared by hydrothermal synthesis. Their implantation in the rat calvarium was followed during 60 days. A total absence of osteoconduction was observed despite a favorable chemical composition, stressing the fundamental role of particle morphology on bone regeneration. Results are discussed in relation with other literature data. Possible explanations include the disfavored accumulation of biological mediators due to the acicular shape of the particles and/or a limited accessibility for cells.

Item Type:Article
Additional Information:Thanks to Trans Tech Publications editor. The definitive version is available at http://www.scientific.net The original PDF of the article can be found at Key Engineering Materials website : http://www.scientific.net/0-87849-457-x/1237/
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Laboratory name:
Deposited On:20 Apr 2009 12:39

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