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Effective biosynthesis of benzoyl-pyrrothine dithiolopyrrolone antibiotic by cinnamic acid-precursor addition in culture of Saccharothrix algeriensis NRRL B-24137

Merrouche, Rabiaa and Yekkour, Amine and Coppel, Yannick and Bouras, Noureddine and Lamari, Lynda and Zitouni, Abdelghani and Mathieu, Florence and Lebrihi, Ahmed and Sabaou, Nasserdine Effective biosynthesis of benzoyl-pyrrothine dithiolopyrrolone antibiotic by cinnamic acid-precursor addition in culture of Saccharothrix algeriensis NRRL B-24137. (2019) Letters in Applied Microbiology, 68 (2). 165-172. ISSN 0266-8254

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Official URL: https://doi.org/10.1111/lam.13101

Abstract

Dithiolopyrrolone antibiotics, produced by several micro‐organisms, are known for their strong antimicrobial and antitumor activities. Among of this micro‐organisms, Saccharothrix algeriensis NRRL B‐24137, a rare actinobacterium, has the ability to produce several dithiolopyrrolones derivatives depending on precursors added in the culture medium. After 10 days of strain fermentation on semi‐synthetic medium supplemented with cinnamic acid and HPLC purification, biosynthesis of benzoyl‐pyrrothine dithiolopyrrolone was evidenced through complete spectroscopic (UV–visible and 1H and 13C NMR) and spectrometric (electron impact mass spectrum) analyses. The pure molecule showed appreciable minimum inhibitory concentration values against several Gram‐positive bacteria and filamentous fungi

Item Type:Article
HAL Id:hal-02052220
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Ecole normale supérieure de Kouba (ALGERIA)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Université de Ghardaïa (ALGERIA)
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Deposited By: Loetitia MOYA
Deposited On:28 Feb 2019 11:57

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