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Unsupervised spectral clustering for segmentation of dynamic PET images

Zbib, Hiba and Mouysset, Sandrine and Stute, Simon and Girault, Jean-Marc and Charara, Jamal and Chalon, Sylvie and Galineau, Laurent and Buvat, Irene and Tauber, Clovis Unsupervised spectral clustering for segmentation of dynamic PET images. (2015) IEEE Transactions on Nuclear Science, 62 (3). 840-850. ISSN 0018-9499

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Official URL: https://doi.org/10.1109/TNS.2015.2399973


Segmentation of dynamic PET images is needed to extract the time activity curves (TAC) of regions of interest (ROI). These TAC can be used in compartmental models for in vivo quantification of the radiotracer target. While unsupervised clustering methods have been proposed to segment PET sequences, they are often sensitive to initial conditions or favour convex shaped clusters. Kinetic spectral clustering (KSC) of dynamic PET images was recently proposed to handle arbitrary shaped clusters in the space in which they are identified. While improved results were obtained with KSC compared to three state of art methods, its use for clinical applications is still hindered by the manual setting of several parameters. In this paper, we develop an extension of KSC to automatically estimate the parameters involved in the method and to make it deterministic. First, a global search procedure is used to locate the optimal cluster centroids from the projected data. Then an unsupervised clustering criterion is tailored and used in a global optimization scheme to automatically estimate the scale parameter and the weighting factors involved in the proposed Automatic and Deterministic Kinetic Spectral Clustering (AD-KSC). We validate the method using GATE Monte Carlo simulations of dynamic numerical phantoms and present results on real dynamic images. The deterministic results obtained with AD-KSC agree well with those obtained with optimal manual parameterization of KSC, and improve the ROI identification compared to three other clustering methods. The proposed approach could have significant impact for quantification of dynamic PET images in molecular imaging studies.

Item Type:Article
Additional Information:Thanks to IEEE editor. The definitive version is available at http://ieeexplore.ieee.org The original PDF can be found at IEEE Transactions in Nuclear Science(ISSN 0018-9499) website : https://ieeexplore.ieee.org/document/7067450 Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
HAL Id:hal-02191817
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Commissariat à l'Energie Atomique et aux énergies alternatives - CEA (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Other partners > Lebanese University - LU (LEBANON)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Université de Toulouse > Université Toulouse - Jean Jaurès - UT2J (FRANCE)
Université de Toulouse > Université Toulouse 1 Capitole - UT1 (FRANCE)
Other partners > Université de Tours (FRANCE)
Laboratory name:
CNRS : Centre national de la recherche scientifique (Liban) - Lebanese University (Liban) - European Union’s Seventh Framework Programme (FP7/2007-2013)
Deposited On:09 Jul 2019 08:10

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