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Direct patterning of nanoparticles and biomolecules by liquid nanodispensing

Fabié, Laure and Agostini, Pierre and Stopel, Martijn and Blum, Christian and Lassagne, Benjamin and Subramaniam, Vinod and Ondarçuhu, Thierry Direct patterning of nanoparticles and biomolecules by liquid nanodispensing. (2015) Nanoscale, 7 (10). 4497-4504. ISSN 2040-3364

(Document in English)

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Official URL: https://doi.org/10.1039/c4nr06824f


We report on the localized deposition of nanoparticles and proteins, nano-objects commonly used in many nanodevices, by the liquid nanodispensing (NADIS) technique which consists in depositing droplets of a solution through a nanochannel drilled at the apex of an AFM tip. We demonstrate that the size of spots can be adjusted from microns down to sub-50 nm by tuning the channel diameter, independently of the chemical nature of the solute. In the case of nanoparticles, we demonstrated the ultimate limit of the method and showed that large arrays of single (or pairs of) nanoparticles can be reproducibly deposited. We further explored the possibility to deposit different visible fluorescent proteins using NADIS without loss of protein function. The intrinsic fluorescence of these proteins is characteristic of their structural integrity; the retention of fluorescence after NADIS deposition demonstrates that the proteins are intact and functional. This study demonstrates that NADIS can be a viable alternative to other scanning probe lithography techniques since it combines high resolution direct writing of nanoparticles or biomolecules with the versatility of liquid lithography techniques.

Item Type:Article
HAL Id:hal-01715937
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National des Sciences Appliquées de Toulouse - INSA (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > FOM Institute AMOLF (NETHERLANDS)
Other partners > University of Twente (NETHERLANDS)
Laboratory name:
Agence nationale de la recherche (FRANCE) - Centre d'Elaboration de Matériaux et d'Etudes Structurales - CEMES (FRANCE) - MESA+ Institute for Nanotechnology, University of Twente (THE NETHERLANDS)
Deposited On:09 Nov 2018 08:59

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