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A novel hydroxamic acid-containing antibiotic produced by a Saharan soil-living Streptomyces strain

Yekkour, Amine and Meklat, Atika and Bijani, Christian and Toumatia, Omrane and Errakhi, Rafik and Lebrihi, Ahmed and Mathieu, Florence and Zitouni, Abdelghani and Sabaou, Nasserdine A novel hydroxamic acid-containing antibiotic produced by a Saharan soil-living Streptomyces strain. (2015) Letters in Applied Microbiology, 60 (6). 589-596. ISSN 0266-8254

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Official URL: https://doi.org/10.1111/lam.12412


During screening for potentially antimicrobial actinobacteria, a highly antagonistic strain, designated WAB9, was isolated from a Saharan soil of Algeria. A polyphasic approach characterized the strain taxonomically as a member of the genus Streptomyces. The strain WAB9 exhibited a broad spectrum of antimicrobial activity toward various multidrug‐resistant micro‐organisms. A PCR‐based assay of genomic potential for producing bioactive metabolites revealed the presence of PKS‐II gene. After 6 days of strain fermentation, one bioactive compound was extracted from the remaining aqueous phase and then purified by HPLC. The chemical structure of the compound was determined by spectroscopic (UV–visible, and 1H and 13C NMR) and spectrometric analysis. The compound was identified to be 2‐amino‐N‐(2‐amino‐3‐phenylpropanoyl)‐N‐hydroxy‐3‐phenylpropanamide, a novel hydroxamic acid‐containing molecule. The pure molecule showed appreciable minimum inhibitory concentration values against a selection of drug‐resistant bacteria, filamentous fungi and yeasts.

Item Type:Article
HAL Id:hal-01938007
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Ecole normale supérieure de Kouba (ALGERIA)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Institut National de la Recherche Agronomique d'Algérie - INRAA (ALGERIE)
Other partners > Université Moulay Ismaïl de Meknès (MOROCCO)
Laboratory name:
Deposited On:01 Oct 2018 12:41

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