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Early events induced by the toxin deoxynivalenol lead to programmed cell death in Nicotiana tabacum cells

Yekkour, Amine and Tran, Daniel and Arbelet-Bonnin, Delphine and Briand, Joël and Mathieu, Florence and Lebrihi, Ahmed and Errakhi, Rafik and Sabaou, Nasserdine and Bouteau, François Early events induced by the toxin deoxynivalenol lead to programmed cell death in Nicotiana tabacum cells. (2015) Plant Science, 238. 148-157. ISSN 0168-9452

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Official URL: https://doi.org/10.1016/j.plantsci.2015.06.004


Deoxynivalenol (DON) is a mycotoxin affecting animals and plants. This toxin synthesized by Fusarium culmorum and Fusarium graminearum is currently believed to play a decisive role in the fungal phytopathogenesis as a virulence factor. Using cultured cells of Nicotiana tabacum BY2, we showed that DON-induced programmed cell death (PCD) could require transcription and translation processes, in contrast to what was observed in animal cells. DON could induce different cross-linked pathways involving (i) reactive oxygen species (ROS) generation linked, at least partly, to a mitochondrial dysfunction and a transcriptional down-regulation of the alternative oxidase (Aox1) gene and (ii) regulation of ion channel activities participating in cell shrinkage, to achieve PCD.

Item Type:Article
HAL Id:hal-01917337
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Ecole normale supérieure de Kouba (ALGERIA)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Other partners > Université de Paris Diderot - Paris 7 (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Institut National de la Recherche Agronomique d'Algérie - INRAA (ALGERIE)
Other partners > Université Moulay Ismaïl de Meknès (MOROCCO)
Laboratory name:
Deposited On:08 Nov 2018 13:08

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