Belghit, Said and Driche, El Hadj and Bijani, Christian and Zitouni, Abdelghani and Sabaou, Nasserdine and Badji, Boubekeur and Mathieu, Florence
Activity of 2,4-Di-tert-butylphenol produced by a strain of Streptomyces mutabilis isolated from a Saharan soil against Candida albicans and other pathogenic fungi.
(2016)
Journal de Mycologie Médicale / Journal of Medical Mycology, 26 (2). 160-169. ISSN 1156-5233
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(Document in English)
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Official URL: https://doi.org/10.1016/j.mycmed.2016.03.001
Abstract
In a search for new antifungal antibiotics active against Candida albicans and others pathogenic fungi, a strain of actinobacteria, designated G61, was isolated from a Saharan soil and tested for its activity against these microorganisms. The analysis of its 16S rDNA sequence showed a similarity level of 100% with Streptomyces mutabilis NBRC 12800T. The highest anticandidal activities produced by the strain G61 were obtained on Bennett medium in the fourth day of incubation. The active product, extracted by n-butanol, contained one bioactive spot detected on thin layer chromatography plates. It was purified by HPLC and its chemical structure was determined by spectroscopic analyses as 2,4-Di-tert-butylphenol. The minimum inhibitory concentrations (MIC) of this product against several strains of pathogenic microorganisms are interesting.
Item Type: | Article |
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HAL Id: | hal-01938085 |
Audience (journal): | International peer-reviewed journal |
Uncontrolled Keywords: | |
Institution: | French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE) Other partners > Ecole normale supérieure de Kouba (ALGERIA) Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE) Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE) |
Laboratory name: | |
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Deposited On: | 31 Oct 2018 11:14 |
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