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Antimicrobial activity of saquayamycins produced by Streptomyces spp. PAL114 isolated from a Saharan soil

Aouiche, Adel and Bijani, Christian and Zitouni, Abdelghani and Mathieu, Florence and Sabaou, Nasserdine Antimicrobial activity of saquayamycins produced by Streptomyces spp. PAL114 isolated from a Saharan soil. (2014) Journal de Mycologie Médicale / Journal of Medical Mycology, 24 (2). e17-e23. ISSN 1156-5233

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Official URL: https://doi.org/10.1016/j.mycmed.2013.09.001


A new strain of actinomycete designated PAL114, producing antimicrobial compounds, was isolated from a Saharan soil in Ghardaïa, Algeria. Morphological and chemical studies showed that this strain belonged to the genus Streptomyces. Two bioactive compounds, named P41A and P41B, were extracted by dichloromethane from the cell-free supernatant broth of strain PAL114 and were purified by HPLC. Minimum inhibitory concentrations of the pure antibiotics were determined against yeasts, filamentous fungi and bacteria, most of which are pathogenic or toxigenic for human and multiresistant to antibiotics. The strongest activities were observed against Candida albicans M3 and Bacillus subtilis ATCC 6633. The chemical structures of the compounds were determined by spectroscopic analysis of UV–visible and 1H and 13C NMR spectra and spectrometric analysis of mass spectrum. The compounds P41A and P41B were identified as saquayamycins A and C, respectively. These compounds belong to the aquayamycin-group antibiotics, which are known in the literature for their anticancer and antibacterial activities.

Item Type:Article
HAL Id:hal-01896725
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Ecole normale supérieure de Kouba (ALGERIA)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Deposited On:16 Oct 2018 12:03

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