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Synthesis,antimicrobial activity and physico-chemical properties of some n-alkyldimethylbenzylammonium halides

El Hage, Salomé and Lajoie Halova, Barbora and Stigliani, Jean-Luc and Furiga, Aurélie and Roques, Christine and Baziard, Geneviève Synthesis,antimicrobial activity and physico-chemical properties of some n-alkyldimethylbenzylammonium halides. (2014) Journal of Applied Biomedicine, 12 (4). 245-253. ISSN 1214-021X

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Official URL: https://doi.org/10.1016/j.jab.2014.02.002


Quaternary ammonium salts (chloride, bromide and iodide; QUATs) with n-alkyl chain lengths between C8 and C18 have been synthesized under optimized experimental conditions. These compounds were tested in vitro for antimicrobial activity against representative bacterial strains (Staphylococcus aureus CIP 4.83, Enterococcus hirae CIP 5855, Pseudomonas aeruginosa CIP 82118, Escherichia coli CIP 53126, Mycobacterium smegmatis CIP 7326) and fungal species (Aspergillus niger ATCC 16404, Candida albicans IP 118079, Trichophyton interdigitale IP 146583). While these compounds showed moderate antifungal activity, several of them (particularly C14-I−) may be considered as highly potential antibacterial agents against S. aureus, E. hirae and E. coli with MIC values lower than that of commercial benzalkonium chloride and ciprofloxacin used as standards. The relationship between the lipophilicity and the antibacterial activity of the tested QUATs was quantified by a multiple linear regression method.

Item Type:Article
HAL Id:hal-02139215
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Deposited On:13 Jul 2018 10:37

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