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Numerical and in vitro experimental study of arterial deformation and buckling under hypertension and atherosclerotic conditions

Assemat, Pauline and Hannema, Gwenael and Carberry, Josie and Mitchell, Danielle and Andrews, Karen and Dart, Anthony and Chin-Dusting, Jaye and Hourigan, Kerry Numerical and in vitro experimental study of arterial deformation and buckling under hypertension and atherosclerotic conditions. (2012) In: 18th Australasian Fluid Mechanics Conference Launceston, Australia, 3 December 2012 - 7 December 2012 (Launceston, Australia).

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Abstract

Cardiovascular diseases remain the major cause of mortality worldwide. Pathologies of the vasculature such as atherosclerosis are often related to biochemical and genetic factors as well as mechanical effects that strongly change the function and shape of arteries. The present work is part of a general research project which aims to better understand the mechanical mechanisms responsible for atherosclerotic plaque formation and rupture. The chosen approach is to use numerical fluidstructure interaction (FSI) methods to study the relative influence of hemodynamic parameters on the structural stresses generated on plaques. To this aim, a numerical study of a simplified straight vessel exposed to lumen pressure was investigated under quiescent and steady flow conditions. As the internal pressure or the steady velocity increases, the vessel buckles lead-ing to a non-linear large deformation behaviour. The results have been validated using theoretical predictions for the buckling thresholds. Further studies on idealised cardiovascular conditions such as stenosis (i.e., lumen constriction) or aneurysm like (i.e., arterial wall expansion) formation have also been performed.

Item Type:Conference or Workshop Item (Paper)
Additional Information:Thanks to 18th Australasian Fluid Mechanics Conference Launceston, Australia : https://www.18afmc.com.au
HAL Id:hal-01814197
Audience (conference):International conference proceedings
Uncontrolled Keywords:
Institution:Other partners > Baker Heart and Diabetes Institute (AUSTRALIA)
Other partners > Monash University (AUSTRALIA)
Laboratory name:
Funders:
Australian Research Council
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Deposited By: Pauline ASSEMAT
Deposited On:13 Jun 2018 06:18

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