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Elaboration and evaluation of alginate foam scaffolds for soft tissue engineering

Ceccaldi, Caroline and Bushkalova, Raya and Cussac, Daniel and Duployer, Benjamin and Tenailleau, Christophe and Bourin, Philippe and Parini, Angelo and Sallerin, Brigitte and Girod-Fullana, Sophie Elaboration and evaluation of alginate foam scaffolds for soft tissue engineering. (2017) International Journal of Pharmaceutics, 524 (1-2). 433-442. ISSN 0378-5173

(Document in English)

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Official URL: http://dx.doi.org/10.1016/j.ijpharm.2017.02.060


Controlling microarchitecture in polymer scaffolds is a priority in material design for soft tissue applications. This paper reports for the first time the elaboration of alginate foam-based scaffolds for mesenchymal stem cell (MSC) delivery and a comparative study of various surfactants on the final device performance. The use of surfactants permitted to obtain highly interconnected porous scaffolds with tunable pore size on surface and in cross-section. Their mechanical properties in compression appeared to be adapted to soft tissue engineering. Scaffold structures could sustain MSC proliferation over 14 days. Paracrine activity of scaffold-seeded MSCs varied with the scaffold structure and growth factors release was globally improved in comparison with control alginate scaffolds. Our results provide evidence that exploiting different surfactant types for alginate foam preparation could be an original method to obtain biocompatible scaffolds with tunable architecture for soft tissue engineering.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at :https://www.sciencedirect.com/science/article/pii/S037851731730159X
HAL Id:hal-01757415
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Etablissement Français du Sang - EFS Midi-Pyrénées (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
Laboratory name:
Deposited On:03 Apr 2018 14:38

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