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Insight into the transport mechanism of solute removed in dialysis by a membrane with double functionality

Snisarenko, Dmytro and Pavlenko, Denys and Stamatialis, Dimitrios and Aimar, Pierre and Causserand, Christel and Bacchin, Patrice Insight into the transport mechanism of solute removed in dialysis by a membrane with double functionality. (2017) Chemical Engineering Research and Design, 126. 97-108. ISSN 0263-8762

(Document in English)

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Official URL: http://dx.doi.org/10.1016/j.cherd.2017.08.017


The present study aims at shedding light on the transport mechanisms involved in a functionalized membrane designed for improving hemodialysis. This membrane is prepared by embedding absorptive micro particles within its porous structure. To understand the transport mechanism through the membrane and make suggestions for its optimization, a mathematical model coupling convection, diffusion and adsorption is developed and validated by comparison of experimental and theoretical results. In fact, the model provides a description of the concentration profile from the donor (feed) compartment across the several layers with different properties to the acceptor (dialysate) compartment. In addition, the model allows to predict the influence of various parameters such as molecule diffusivity, membrane thickness, presence of convection, content of adsorptive particles on the flux intensification across the membrane. Comparison with experimental measurements demonstrates that the model is able to describe the transmembrane mass flux variation over time as a function of hydrodynamic conditions and membrane/module geometric parameters. The model also illustrates how the proposed double-layer membrane concept offers significant benefits in terms of toxin removal in comparison to conventional dialysis. As so, the main achievement of the developed model is that it may serve as tool for the further improvement of functionalized membrane in terms of toxin removal and optimization of process conditions

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com/science/article/pii/S026387621730429X
HAL Id:hal-03513966
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > University of Twente (NETHERLANDS)
Laboratory name:
Deposited On:20 Oct 2017 12:54

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