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Analysis of vascular homogeneity and anisotropy on high-resolution primate brain imaging

Kennel, Pol and Fonta, Caroline and Guibert, Romain and Plouraboué, Franck Analysis of vascular homogeneity and anisotropy on high-resolution primate brain imaging. (2017) Human Brain Mapping. 1-22. ISSN 1065-9471 (Unpublished)

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Official URL: http://dx.doi.org/10.1002/hbm.23766

Abstract

Using a systematic investigation of brain blood volume, in high-resolution synchrotron 3D images of microvascular structures within cortical regions of a primate brain, we challenge several basic questions regarding possible vascular bias in high-resolution functional neuroimaging. We present a bilateral comparison of cortical regions, where we analyze relative vascular volume in voxels from 150 to 1000 lm side lengths in the white and grey matter. We show that, if voxel size reaches a scale smaller than 300 mm, the vascular volume can no longer be considered homogeneous, either within one hemisphere or in bilateral comparison between samples. We demonstrate that voxel size influences the comparison between vessel-relative volume distributions depending on the scale considered (i.e., hemisphere, lobe, or sample). Furthermore, we also investigate how voxel anisotropy and orientation can affect the apparent vascular volume, in accordance with actual fMRI voxel sizes. These findings are discussed from the various perspectives of high-resolution brain functional imaging

Item Type:Article
Additional Information:Thanks to Wiley editor. The original PDF of the article can be found at http://onlinelibrary.wiley.com/doi/10.1002/hbm.23766/abstract;jsessionid=DDD19D105E91234E0B3CC57B24E0FC9A.f04t01
HAL Id:hal-01590915
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
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Deposited On:20 Sep 2017 12:17

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