Schardosim, Mariane and Soulié, Jérémy
and Poquillon, Dominique
and Cazalbou, Sophie
and Duployer, Benjamin
and Tenailleau, Christophe
and Rey, Christian
and Hübler, Roberto and Combes, Christèle
Freeze-casting for PLGA/carbonated apatite composite scaffolds: structure and properties.
(2017)
Materials Science and Engineering C, 77. 731-738. ISSN 0928-4931
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(Document in English)
PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 1MB |
Official URL: http://dx.doi.org/10.1016/j.msec.2017.03.302
Abstract
This paper focuses on the fabrication of three-dimensional porous PLGA-biomimetic carbonated apatite composite scaffolds by freeze-casting and using dimethyl carbonate as a solvent. Several charge/polymer ratios were tested in order to finely understand the influence of the filler rate on the scaffold porosity and mechanical and degradation properties using complementary characterization techniques (SEM, mercury porosimetry and X-ray microtomography). It was demonstrated that the apatite ratio within the composite scaffold has a strong influence in terms of architecture, material cohesion, mechanical properties and in vitro degradation properties. An optimum biomimetic apatite ratio was reached to combine good mechanical properties (higher rigidity) and material cohesion. In vitro degradation studies showed that higher apatite filler rates limited PLGA degradation and enhanced the hydrophilicity of the scaffolds which is expected to improve the biological properties of the scaffolds in addition to the bioactivity related to the presence of the apatite analogous to bone mineral.
Item Type: | Article |
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Additional Information: | Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at : http://www.sciencedirect.com/science/article/pii/S0928493116327941 |
HAL Id: | hal-01623713 |
Audience (journal): | International peer-reviewed journal |
Uncontrolled Keywords: | |
Institution: | French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE) Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE) Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE) Other partners > Pontificia Universidade Catolica do Rio Grande do Sul - PUCRS (BRAZIL) |
Laboratory name: | |
Funders: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES - FERMaT Midi-Pyrénées Federation FR3089 |
Statistics: | download |
Deposited On: | 25 Oct 2017 13:30 |
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