Piotrowska, Urszula and Sobczak, Marcin and Oledzka, Ewa and Combes, Christèle
Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B.
(2016)
Journal of Applied Polymer Science, 133 (31). ISSN 0021-8995
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(Document in English)
PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 597kB |
Official URL: http://dx.doi.org/10.1002/app.43728
Abstract
The study provides detailed information on the differences in the structural, thermal and degradation properties of poly(e-caprolactone) synthesized in two different ionic liquids, 1-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6] and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [bmim][NTf2], regarding its further usage in the pharmaceutical field. The polymer structure confirms the presence of both linear polymer chains with end-functional hydroxyl groups allowing covalent coupling of the therapeutic agents, and cyclic macromolecules, both affecting the degree of crystallinity of polymer. The highest macrocyclic content (64%) after 7 days of polymerization at 80 8C was observed for [bmim][NTf2]. For [bmim][PF6], the macrocyclic content value was not dependent on the reaction time and remained at a similar level (10–14% at 80 8C). The results of degradation test revealed that hydrolytic degradation of ester bonds is more pronounced for PCLs synthesized in [bmim][NTf2], due to their lower degree of crystallinity compared with PCLs obtained in [bmim][PF6]. A high purity, low polydispersity index of the obtained polymers and high yield of the process (ca., 90%) indicate that ionic liquids seem to be promising solvents for the synthesis of biomedical polymers.
Item Type: | Article |
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Additional Information: | Thanks to John Wiley & Sons editor. The definitive version is available at : http://onlinelibrary.wiley.com/doi/10.1002/app.43728/epdf |
HAL Id: | hal-01644363 |
Audience (journal): | International peer-reviewed journal |
Uncontrolled Keywords: | |
Institution: | French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE) Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE) Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE) Other partners > Kazimierz Pułaski University of Technology and Humanities in Radom (POLAND) Other partners > Medical University of Warsaw - WUM (POLAND) |
Laboratory name: | |
Funders: | National Science Centre (Poland) - Medical University of Warsaw - Violetta Kowalsk - Monika Pisklak - Agnieszka Sokal |
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Deposited On: | 22 Nov 2017 10:00 |
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