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Sensitivity analysis of periprosthetic healing to cell migration, growth factor and post-operative gap using a mechanobiological model

Swider, Pascal and Ambard, Dominique and Guérin, G. and Søballe, Kjeld and Bechtold, Joan E. Sensitivity analysis of periprosthetic healing to cell migration, growth factor and post-operative gap using a mechanobiological model. (2011) Computer Methods in Biomechanics and Biomedical Engineering, 14 (9). 763-771. ISSN 1025-5842

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Official URL: http://dx.doi.org/10.1080/10255842.2010.494160

Abstract

A theoretical rationale, which could help in the investigation of mechanobiological factors affecting periprosthetic tissue healing, is still an open problem. We used a parametric sensitivity analysis to extend a theoretical model based on reactive transport and computational cell biology. The numerical experimentation involved the drill hole, the haptotactic and chemotactic migrations, and the initial concentration of an anabolic growth factor. Output measure was the mineral fraction in tissue surrounding a polymethymethacrylate (PMMA) canine implant (stable loaded implant, non-critical gap). Increasing growth factor concentration increased structural matrix synthesis. A cell adhesion gradient resulted in heterogeneous bone distribution and a growth factor gradient resulted in homogeneous bone distribution in the gap. This could explain the radial variation of bone density from the implant surface to the drill hole, indicating less secure fixation. This study helps to understand the relative importance of various host and clinical factors influencing bone distribution and resulting implant fixation.

Item Type:Article
Additional Information:Thanks to Taylor & Francis editor. The original PDF of the article can be found at http://www.tandfonline.com/doi/abs/10.1080/10255842.2010.494160
HAL Id:hal-01590828
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Aarhus Universitet (DENMARK)
Other partners > Minneapolis Medical Research Foundation - MMRF (USA)
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Deposited On:20 Sep 2017 11:00

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