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Wave front migration of endothelial cells in a bone-implant interface

Khalil, Georges and Lorthois, Sylvie and Marcoux, Manuel and Mansat, Pierre and Swider, Pascal Wave front migration of endothelial cells in a bone-implant interface. (2011) Journal of Biomechanics, 44 (10). 1980-1986. ISSN 0021-9290

(Document in English)

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Official URL: http://dx.doi.org/10.1016/j.jbiomech.2011.05.008


The neo-vascularization of the host site is crucial for the primary fixation and the long-term stability of the bone-implant interface. Our aim was to investigate the progression of endothelial cell population in the first weeks of healing. We proposed a theoretical reactive model to study the role of initial conditions, random motility, haptotaxis and chemotaxis in interactions with fibronectin factors and transforming angiogenic factors. The application of governing equations concerned a canine experimental implant and numerical experiments based upon statistical designs of experiments supported the discussion. We found that chemotaxis due to transforming angiogenic factors was attracting endothelial cells present into the host bone. Haptotaxis conditioned by fibronectin factors favored cells adhesion to the host bone. The combination of diffusive and reactive effects nourished the wave front migration of endothelial cells from the host bone towards the implant. Angiogenesis goes together with new-formed bone formation in clinics, so the similarity of distribution patterns of mineralized tissue observed in-vivo and the spatio-temporal concentration of endothelial cells predicted by the model, tended to support the reliability of our theoretical approach.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The original PDF of the article can be found at http://www.sciencedirect.com/science/article/pii/S0021929011003976
HAL Id:hal-01589942
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
Laboratory name:
Deposited On:19 Sep 2017 09:24

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