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Influence of fluid-flow direction on effective permeability of the vertebral end plate: an analytical model

Swider, Pascal and Accadbled, Franck and Laffosse, Jean-Michel and Sales de Gauzy, Jérôme Influence of fluid-flow direction on effective permeability of the vertebral end plate: an analytical model. (2012) Computer Methods in Biomechanics and Biomedical Engineering, 15 (2). 151-156. ISSN 1025-5842

(Document in English)

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Official URL: http://dx.doi.org/10.1080/10255842.2010.518960


Convective transports in the vertebral end plate (VEP) play a significant role in the homeostasis of the spine. A few studies hypothesised that the hydraulic resistance or effective permeability of the VEP could be dependant upon fluid-flow direction. Results were influenced by species, region of interest within the end plate and pathology. Some results were contradictory. We propose an analytical model based on steady-state Newtonian flows in capillary media to develop a phenomenological analysis of convective transport through the VEP. This dependence was established using a biquadratic analytical function involving porosities of subchondral bone, capillary bed and cartilage end plate. Discussion of results provided a theoretical justification for variable and/or contradictory experimental results concerning the amount of energy lost by fluid during its course through the end plate. Tissue porosities and, especially, those relative to the capillary bed could strongly influence the dependence of fluid energy loss on flow direction and could potentially modify tissue homeostasis related to the day and night cycle.

Item Type:Article
Additional Information:Thanks to Taylor & Francis editor. The original PDF of the article can be found at http://www.tandfonline.com/doi/abs/10.1080/10255842.2010.518960
HAL Id:hal-01589888
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
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Deposited On:19 Sep 2017 09:10

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