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Qualitative and Semiquantitative Assessment of Exposure to Engineered Nanomaterials within the French EpiNano Program: Inter- and Intramethod Reliability Study

Guseva Canu, Irina and Jezewski-Serra, Delphine and Delabre, Laurène and Ducamp, Stéphane and Iwatsubo, Yuriko and Audignon-Durand, Sabine and Ducros, Cécile and Radauceanu, Anca and Durand, Catherine and Witschger, Olivier and Flahaut, Emmanuel Qualitative and Semiquantitative Assessment of Exposure to Engineered Nanomaterials within the French EpiNano Program: Inter- and Intramethod Reliability Study. (2017) The Annals of Occupational Hygiene, 61 (1). 87-97. ISSN 1475-3162

(Document in English)

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Official URL: http://dx.doi.org/10.1093/annweh/wxw008


The relatively recent development of industries working with nanomaterials has created challenges for exposure assessment. In this article, we propose a relatively simple approach to assessing nanomaterial exposures for the purposes of epidemiological studies of workers in these industries. This method consists of an onsite industrial hygiene visit of facilities carried out individually and a description of workstations where nano-objects and their agglomerates and aggregates (NOAA) are present using a standardized tool, the Onsite technical logbook. To assess its reliability, we implemented this approach for assessing exposure to NOAA in workplaces at seven workstations which synthesize and functionalize carbon nanotubes. The prediction of exposure to NOAA using this method exhibited substantial agreement with that of the reference method, the latter being based on an onsite group visit, an expert’s report and exposure measurements (Cohen kappa = 0.70, sensitivity = 0.88, specificity = 0.92). Intramethod comparison of results for exposure prediction showed moderate agreement between the three evaluators (two program team evaluators and one external evaluator) (weighted Fleiss kappa = 0.60, P = 0.003). Interevaluator reliability of the semiquantitative exposure characterization results was excellent between the two evaluators from the program team (Spearman rho = 0.93, P = 0.03) and fair when these two evaluators’ results were compared with the external evaluator’s results. The project was undertaken within the framework of the French epidemiological surveillance program EpiNano. This study allowed a first reliability assessment of the EpiNano method. However, to further validate this method a comparison with robust quantitative exposure measurement data is necessary.

Item Type:Article
Additional Information:Thanks to Oxford University Press editor. The definitive version is available at https://academic.oup.com/ The original PDF of the article can be found at https://academic.oup.com/annweh/article-abstract/61/1/87/2762734/Qualitative-and-Semiquantitative-Assessment-of?redirectedFrom=fulltext
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Commissariat à l'Energie Atomique et aux énergies alternatives - CEA (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Other partners > Institut National de Recherche et Sécurité - INRS (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Université de Bordeaux 2 - Victor Segalen (FRANCE)
French research institutions > Santé publique France (FRANCE)
Laboratory name:
Deposited On:15 Jun 2017 07:26

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