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Red wine and pomegranate extracts suppress cured meat promotion of colonic mucin-depleted foci in carcinogen-induced rats

Bastide, Nadia and Naud, Nathalie and Nassy, Gilles and Vendeuvre, Jean-Luc and Taché, Sylviane and Guéraud, Françoise and Hobbs, Ditte A. and Kuhnle, Gunter and Corpet, Denis E. and Pierre, Fabrice Red wine and pomegranate extracts suppress cured meat promotion of colonic mucin-depleted foci in carcinogen-induced rats. (2017) Nutrition and Cancer, 69 (2). 289-298. ISSN 0163-5581

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Official URL: http://dx.doi.org/10.1080/01635581.2017.1263745

Abstract

Processed meat intake is carcinogenic to humans. We have shown that intake of a workshop-made cured meat with erythorbate promotes colon carcinogenesis in rats. We speculated that polyphenols could inhibit this effect by limitation of endogenous lipid peroxidation and nitrosation. Polyphenol-rich plant extracts were added to the workshop-made cured meat and given for 14 days to rats and 100 days to azoxymethane-induced rats to evaluate the inhibition of preneoplastic lesions. Colons of 100-d study were scored for precancerous lesions (mucin-depleted foci, MDF), and biochemical end points of peroxidation and nitrosation were measured in urinary and fecal samples. In comparison with cured meat-fed rats, dried red wine, pomegranate extract, a-tocopherol added at one dose to cured meat and withdrawal of erythorbate significantly decreased the number of MDF per colon (but white grape and rosemary extracts did not). This protection was associated with the full suppression of fecal excretion of nitrosyl iron, suggesting that this nitroso compound might be a promoter of carcinogenesis. At optimized concentrations, the incorporation of these plant extracts in cured meat might reduce the risk of colorectal cancer associated with processed meat consumption.

Item Type:Article
Additional Information:Thanks to Taylor & Francis editor. The definitive version is available at http://www.tandfonline.com/ The original PDF of the article can be found at Nutrition and Cancer website : http://www.tandfonline.com/doi/full/10.1080/01635581.2017.1263745
HAL Id:hal-01564455
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
Other partners > Institut du Porc - IFIP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > University of Reading (UNITED KINGDOM)
Laboratory name:
Funders:
Institut National de la Recherche Agronomique - INRA (France) - Institut Français du Porc - IFIP (France)
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Deposited On:23 Feb 2017 08:00

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