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Examining the impact of multi-layer graphene using cellular and amphibian models

Muzi, Laura and Mouchet, Florence and Cadarsi, Stéphanie and Janowska, Izabela and Russier, Julie and Ménard-Moyon, Cécilia and Risuleo, Gianfranco and Soula, Brigitte and Galibert, Anne-Marie and Flahaut, Emmanuel and Pinelli, Eric and Gauthier, Laury and Bianco, Alberto Examining the impact of multi-layer graphene using cellular and amphibian models. (2016) 2D Materials, 3 (2). 025009. ISSN 2053-1583

(Document in English)

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Official URL: http://dx.doi.org/10.1088/2053-1583/3/2/025009


In the last few years, graphene has been defined as the revolutionary material showing an incredible expansion in industrial applications. Different graphene forms have been applied in several contexts, spreading from energy technologies and electronics to food and agriculture technologies. Graphene showed promises also in the biomedical field. Hopeful results have been already obtained in diagnostic, drug delivery, tissue regeneration and photothermal cancer ablation. In view of the enormous development of graphene-based technologies, a careful assessment of its impact on health and environment is demanded. It is evident how investigating the graphene toxicity is of fundamental importance in the context of medical purposes. Onthe other hand, the nanomaterial present in the environment, likely to be generated all along the industrial life-cycle, may have harmful effects on living organisms. In the present work, an important contribution on the impact of multi-layer graphene (MLG) on health and environment is given by using a multifaceted approach. For the first purpose, the effect of the material on two mammalian cell models was assessed. Key cytotoxicity parameters were considered such as cell viability and inflammatory response induction. This was combined with an evaluation ofMLGtoxicity towards Xenopus laevis, used as both in vivo and environmental model organism.

Item Type:Article
Additional Information:Thanks to IOP Publishing editor. The definitive version is available at http://iopscience.iop.org
HAL Id:hal-01462915
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Other partners > Università di Roma - SAPIENZA (ITALY)
Other partners > Université de Strasbourg - UNISTRA (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Deposited On:09 Feb 2017 09:49

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