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Comparison of brain vasculature network characteristics between wild type and Alzheimer’s disease mice using topological metrics

Haft Javaheriam, Mohamad and Muse, Victorine and Cruz Hernández, Jean and Kersbergen, Calvin and Ivasyk, Iryna and Kang, Yiming and Otte, Gabriel and Lorthois, Sylvie and Schaffer, Christopher B. and Nishimura, Nozomi Comparison of brain vasculature network characteristics between wild type and Alzheimer’s disease mice using topological metrics. (2016) In: Neuroscience 2016, 12 November 2016 - 16 November 2016 (San Diego, United States).

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Abstract

There is a strong clinical correlation between Alzheimer’s disease (AD) and microvascular disorders. In mouse models of AD, our lab has found blood flow dysfunction in brain capillaries, suggesting the need to study the function of vascular networks at the capillary level. However, the ability to deliver blood flow continuously to all neurons also depends on connections between vessels, requiring that we also characterize the topology of brain vascular networks. Here, we use graph theory and topological metrics to characterize the connectivity of brain capillary networks in AD and control mice.

Item Type:Conference or Workshop Item (Poster)
Additional Information:Thanks to the Society for Neuroscience. The abstract is available at https://www.sfn.org/annual-meeting/neuroscience-2016
Audience (conference):International conference proceedings
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Cornell University (USA)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
Funders:
European Commission - National Institutes of Health (USA)
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Deposited On:14 Mar 2017 07:57

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