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Redox active Double Wall Carbon Nanotubes show intrinsic anti-proliferative effects and modulate autophagy in cancer cells

Fiorito, Silvana and Flahaut, Emmanuel and Rapino, Stefania and Paolucci, Francesco and Andreola, Federica and Moroni, Noemi and Pittaluga, Eugenia and Zonfrillo, Manuela and Valenti, Giovanni and Mastrofrancesco, Arianna and Groppi, Flavia and Sabbioni, Enrico and Bakalis, Evangelos and Zerbetto, Francesco and Serafino, Annalucia Redox active Double Wall Carbon Nanotubes show intrinsic anti-proliferative effects and modulate autophagy in cancer cells. (2014) Carbon, 78. 589-600. ISSN 0008-6223

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Official URL: http://dx.doi.org/10.1016/j.carbon.2014.07.046


In Double-Walled-Carbon-Nanotubes (DWCNTs) the outer shell screens the inner one from the external environment. As a consequence, the electronic properties of the smaller tube are enhanced and DWCNTs have therefore been advocated for a number of uses. In their raw form theymay contain small metallic clusters, left over from the catalytic process, that can give them a redox activity characterized by redox potentials in the range of one hundred millivolts and able to affect biological systems. Indeed, we find that redox active raw-DWCNTs inhibit rat colorectal cancer cell proliferation by blocking cells in the G2 phase through ROS generation by tumor cells. We show that raw-DWCNTs could also modulate autophagy in tumor cells through induction of intracellular acidification. To the best of our knowledge, this is the first time that DWCNTs have been found to inhibit proliferation and modulate autophagy in cancer cells. Our work further supports previous studies that provided promising results on the possibility of future applications of Carbon Nanotubes (CNTs) in nanomedicine.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at http://www.sciencedirect.com/science/article/pii/S0008622314006848
HAL Id:hal-01465877
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Consiglio Nazionale delle Ricerche - CNR (ITALY)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Other partners > Fondazione Santa Lucia - IRCCS (ITALY)
Other partners > Università di Roma - SAPIENZA (ITALY)
Other partners > Università di Bologna (ITALY)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Università degli Studi di Milano (ITALY)
Other partners > Fondazione Università Gabriele d’Annunzio (ITALY)
Laboratory name:
Deposited On:13 Feb 2017 10:04

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