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Hierarchical analysis and multi-scale modelling of rat cortical and trabecular bone

Oftadeh, Ramin and Entezari, Vahid and Spörri, Guy and Villa-Camacho, Juan Carlos and Krigbaum, Henry and Strawich, Elsa and Graham, Lila and Rey, Christian and Chiu, Hank and Muller, Ralph and Hashemi, Hamid Nayeb and Vaziri, Ashkan and Nazarian, Ara Hierarchical analysis and multi-scale modelling of rat cortical and trabecular bone. (2015) Journal of The Royal Society Interface, 12 (106). 1-16. ISSN 1742-5689

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Official URL: http://dx.doi.org/10.1098/rsif.2015.0070


The aim of this study was to explore the hierarchical arrangement of structural properties in cortical and trabecular bone and to determine a mathematical model that accurately predicts the tissue's mechanical properties as a function of these indices. By using a variety of analytical techniques, we were able to characterize the structural and compositional properties of cortical and trabecular bones, as well as to determine the suitable mathematical model to predict the tissue's mechanical properties using a continuum micromechanics approach. Our hierarchical analysis demonstrated that the differences between cortical and trabecular bone reside mainly at the micro- and ultrastructural levels. By gaining a better appreciation of the similarities and differences between the two bone types, we would be able to provide a better assessment and understanding of their individual roles, as well as their contribution to bone health overall.

Item Type:Article
Additional Information:Thanks to Royal Society editor. The definitive version is available at : http://rsif.royalsocietypublishing.org/
HAL Id:hal-01490594
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Harvard Medical School - HMS (USA)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Boston Children's Hospital (USA)
Other partners > Northeastern University (USA)
Other partners > Eidgenössische Technische Hochschule Zürich - ETHZ (SWITZERLAND)
Other partners > University of Memphis (USA)
Other partners > University of California, San Francisco - UCSF (USA)
Laboratory name:
Deposited On:25 Jan 2017 08:47

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