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Study of the phase separation effect in capillary-size micro-channels

Merlo, Adlan and Duru, Paul and Lorthois, Sylvie Study of the phase separation effect in capillary-size micro-channels. (2016) In: 5th Micro and Nano Flows Conference, 11 September 2016 - 14 September 2016 (Milan, Italy). (Unpublished)

(Document in English)

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It has been known for more than 50 years that the distribution of red blood cells (RBCs) in microvessel networks is highly heterogeneous. Yet, the phase separation effect (PS), i.e the non-proportional distribution of RBCs between the two daughter branches of a simple divergent bifurcation, is still poorly understood especially when RBC concentration (tube hematocrit) reaches high values (> 20%) and when vessel diameter is close to that of RBCs' (~8μm), as often encountered in microcirculation. The most commonly used PS law has been empirically derived in vivo by Pries et al. [1] but its validity has been recently questioned [2]. Therefore, experimental data obtained in controlled conditions are needed. We have designed squared micro-channel bifurcations, with side ranging from 5 to 20 microns, and adapted the injection geometry. Associated to a new method for the measurement of high tube hematocrit values, this allows for an in vitro systematic investigation of the parameters influencing the PS (tube hematocrit, confinement, bifurcation geometry). Our results are compared with Pries' PS law.

Item Type:Conference or Workshop Item (Lecture)
Additional Information:Thanks to 5th Micro and Nano Flows Conference. http://mnf2016.com/
Audience (conference):International conference without published proceedings
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
ERC Consolidator BrainMicroFlow GA615102 - LAAS-CNRS micro and nano technolgies platform member of the French RENATECH network.
Deposited On:18 Oct 2016 12:56

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