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Numerical investigation of subgrid mixing effects on the calculation of biological reaction rates

Linkès, Marion and Fede, Pascal and Morchain, Jérôme and Schmitz, Philippe Numerical investigation of subgrid mixing effects on the calculation of biological reaction rates. (2014) Chemical Engineering Science, 116. 473-485. ISSN 0009-2509

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Official URL: http://dx.doi.org/10.1016/j.ces.2014.05.005


The consequences of substrate concentration heterogeneities at the cell level, on the behavior of microbial populations have been identified some years ago. However, subgrid effects are rarely considered in bioreactor modelling. In this paper, this central issue is investigated with Direct Numerical Simulations (DNS) coupled with Lagrangian particle tracking and scalar field calculations in the case of statistically steady homogeneous and isotropic turbulence. From these calculations, the exact distribution of substrate uptake rates of a microorganism population is calculated and compared, favorably, to analytical solutions. A metabolic model considering anabolism, oxidative catabolism and dissimilation is invoked to quantify the consequences in terms of overall reaction rates at the population scale. It is shown that imperfect mixing reduces the growth rate and increases the by-product formation while leaving the total uptake rate unchanged. This work provides a rational explanation, based on physical consideration, for the loss in biomass productivity and the increase of by-product formation in imperfectly mixed bioreactors.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at Chemical Engineering Science website : http://www.sciencedirect.com/science/article/pii/S0009250914002152
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Recherche Agronomique - INRA (FRANCE)
Université de Toulouse > Institut National des Sciences Appliquées de Toulouse - INSA (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
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Deposited On:13 May 2016 10:48

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