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A Framework for Multiproduct Batch Plant Design with Environmental Consideration: Application To Protein Production

Dietz, Adrian and Azzaro-Pantel, Catherine and Pibouleau, Luc and Domenech, Serge A Framework for Multiproduct Batch Plant Design with Environmental Consideration: Application To Protein Production. (2005) Industrial & Engineering Chemistry Research, 44 (7). 2191-2206. ISSN 0888-5885

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Official URL: https://doi.org/10.1021/ie049499m


This paper presents a framework for optimal design of batch plants. It consists of a master optimization algorithm, i.e., a genetic algorithm (GA) coupled to a discrete-event simulation (DES). The innovative aspect of this work is the use of “shortcut” models included in the DES for describing the unit operations. The example of a protein production process serves as an illustration to show the effectiveness of the approach. The major interest is that the use of local models for unit operations allows the computation of an environmental index in combination with an economic indicator. The optimization framework determines the plant structure (parallel units, allocation of intermediate storage tanks), the batch plant decision variables (equipment sizes, batch sizes) and the process decision variables (e.g., final concentration at selected stages, volumetric ratio of phases at the liquid−liquid extraction, ...). The results show that a plant configuration can be easily improved, only by changing the campaign policy for instance. Optimization results for monocriterion cases (miminization of investment cost and two environmental impact criteria based on biomass produced and amount of solvent used) illustrate the efficiency of the methodology, finding a set of “good” solutions which may be interesting for the decision maker.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Laboratory name:
Laboratoire de Génie Chimique - LGC (Toulouse, France) - Procédés Systèmes Industriels (PSI) - Conception Optimisation Ordonnancement des Procédés (COOP)
Deposited On:19 Nov 2008 10:49

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