Le Bolay, Nadine and Santran, Véronique
and Dechambre, Gérard and Combes, Christèle and Drouet, Christophe and Lamure, Alain and Rey, Christian
Production, by co-grinding in a media mill, of porous biodegradable polylactic acid-apatite composite materials for bone tissue engineering.
(2009)
Powder Technology, 190 (1-2). 89-94. ISSN 0032-5910
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(Document in English)
PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 1MB |
Official URL: http://dx.doi.org/10.1016/j.powtec.2008.04.043
Abstract
This paper presents the results of a study of the production of porous biodegradable composite materials by co-grinding, followed by scaffolding. Dry powders of polylactic acid and nanocrystalline carbonated apatite, analogous to bone mineral were co-ground in a tumbling ball mill in order to disperse the mineral filler within the polymer. Porous scaffolds were then made by hot moulding the mixture of the two components along with a pore-forming agent which was subsequently eliminated by washing. The mechanical resistance of the scaffolds was evaluated in order to determine the best operating conditions to produce implants offering optimised properties for use as bone substitutes. It was shown that 30 wt.% of filler and 70 wt.% of pore-forming agent produce scaffolds which are sufficiently porous and resistant
Item Type: | Article |
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Additional Information: | Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at Powder Technology website : http://www.sciencedirect.com/science/journal/00325910 |
Audience (journal): | International peer-reviewed journal |
Uncontrolled Keywords: | |
Institution: | Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE) Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE) French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE) |
Laboratory name: | Laboratoire de Génie Chimique - LGC (Toulouse, France) - Réaction, mélange & séparation (RMS) Centre Interuniversitaire de Recherche et d'Ingénierie des Matériaux - CIRIMAT (Toulouse, France) |
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Deposited On: | 17 Nov 2008 10:08 |
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