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A mixed approach for modeling blood flow in brain microcirculation

Lorthois, Sylvie and Peyrounette, Myriam and Davit, Yohan and Quintard, Michel A mixed approach for modeling blood flow in brain microcirculation. (2015) In: 68th Annual Meeting of the APS Division of Fluid Dynamics, 22 November 2015 - 24 November 2015 (Boston, United States). (Unpublished)

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Consistent with its distribution and exchange functions, the vascular system of the human brain cortex is a superposition of two components. At small scale, a homogeneous and space-filling mesh-like capillary network. At large scale, quasi-fractal branched veins and arteries. From a modeling perspective, this is the superposition of: (a) a continuum model resulting from the homogenization of slow transport in the small-scale capillary network; and (b) a discrete network approach describing fast transport in the arteries and veins, which cannot be homogenized because of their fractal nature. This problematic is analogous to fast conducting wells embedded in a reservoir rock in petroleum engineering. An efficient method to reduce the computational cost is to use relatively large grid blocks for the continuum model. This makes it difficult to accurately couple both components. We solve this issue by adapting the well model concept used in petroleum engineering to brain specific 3D situations. We obtain a unique linear system describing the discrete network, the continuum and the well model. Results are presented for realistic arterial and venous geometries. The mixed approach is compared with full network models including various idealized capillary networks of known permeability.

Item Type:Conference or Workshop Item (Speech)
Audience (conference):International conference without published proceedings
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Laboratory name:
European Research Council
Deposited On:11 Jan 2016 16:09

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