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Prediction of solid–binder affinity in dry and aqueous systems: Work of adhesion approach vs. ideal tensile strength approach

Jarray, Ahmed and Gerbaud, Vincent and Hemati, Mehrdji Prediction of solid–binder affinity in dry and aqueous systems: Work of adhesion approach vs. ideal tensile strength approach. (2015) Powder Technology, 271. 61-75. ISSN 0032-5910

(Document in English)

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Official URL: http://dx.doi.org/10.1016/j.powtec.2014.11.004


Wet granulation process requiresthe addition of a coating agentor binder, typicallycomposed of surfactants such as hydroxypropyl-methylcellulose (HPMC), water and a small amount offiller such as stearic acid (SA). In dry granulation however, the coating agent is added to the system in the form offine solid particles. In both cases, a successful granulation requires good affinity between host and guest particles. In this study, we compare two approaches to predict the binder–substrate affinity in dry and in aqueous media, one based on the work of adhesion and the other based on the ideal tensile strength (Rowe, 1988). The novelties of this paper are four folds. First, the equations used in both approaches are generalized and rewritten as a function of the Hildebrand solubility parameter δ.δ is obtained from molecular simulations or predicted from HSPiP group contribution method. Secondly, a correlation between δ and the experimental surface tension γ is established for cellulose de-rivative (such as HPMC and ethyl cellulose). Thirdly, the concept of ideal tensile strength, originally formalized by Gardon (1967) for binary systems, is extended to ternary systems and applied for granulation in aqueous media. Fourthly, the approaches are tested for various systems and compared to experimental observations. For dry bi-nary systems, predicted adhesive and cohesive properties agree with literature experimental observations, but the work of adhesion approach performs better than the ideal tensilestrength approach. Both approaches predict thatHPMCisa good binderfor microcrystallinecellulose (MCC).The results alsoindicate that polyethyleneglycol 400(PEG400)has a good affinity with HPMC and stearic acid. For ternary aqueous systems, the results fully agree with the observations of Laboulfie et al.(2013).

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at Powder Technology website : http://www.sciencedirect.com/science/journal/00325910
HAL Id:hal-03519035
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
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Deposited On:30 Sep 2015 08:45

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