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Biomimetic Apatite-Based Functional Nanoparticles as Promising Newcomers in Nanomedicine: Overview of 10 Years of Initiatory Research

Drouet, Christophe and Al-Kattan, Ahmed and Choimet, Maëla and Tourrette, Audrey and Santran, Véronique and Dexpert-Ghys, Jeannette and Pipy, Bernard and Brouillet, Fabien and Tourbin, Mallorie Biomimetic Apatite-Based Functional Nanoparticles as Promising Newcomers in Nanomedicine: Overview of 10 Years of Initiatory Research. (2015) Journal of General Practice and Medical Diagnosis, 1 (1). 1-9.

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Official URL: http://www.heraldopenaccess.us/fulltext/General-Practice-&-Medical-Diagnosis/Biomimetic-Apatite-Based-Functional-Nanoparticles-as-Promising-Newcomers-in-Nanomedicine-Overview-of-10-Years-of-Initiatory-Research.php


Biomimetic calcium phosphate apatites, analogous to bone mineral, may now be produced synthetically. Their intrinsic biocompatibility and the nanometer dimensions of their constitutive crystals not only allow one to envision applications in bone tissue regeneration, but also in other medical fields such as nanomedicine, and in particular in view of cell diagnosis. In this mini-review, we look back at 10 years of our dedicated research, and summarize the main advances made in terms of preparation, physical-chemical characterizations and biological evaluations of colloidal formulations of biomimetic apatite-based nanoparticles, which we illustrate here with the angle of cancer diagnosis. The confirmed exceptional biocompatibility of these engineered nanoparticles, associated to the possibility to confer them luminescence properties by way of controlled lanthanide doping, and their capacity to be internalized by cells, including with cancer cell addressing abilities (shown here as a proof of concept), underline that biomimetic apatite-based colloidal nanoparticles are particularly promising for nanomedicine applications, for example related to diseased cells diagnosis. Multidisciplinary research on these functional nanoparticles, initiated as described here, has now generated emulation in the scientific community where the concept of apatite nanoparticles for nanomedicine is being, gratifyingly, appropriated.

Item Type:Article
Additional Information:Thanks to Herald Scholarly Open Access editor. The definitive version is available at http://www.heraldopenaccess.us The original PDF of the article can be found at Herald Scholarly Open Access website : Herald Scholarly Open Access/fulltext/General-Practice-&-Medical-Diagnosis/Biomimetic-Apatite-Based-Functional-Nanoparticles-as-Promising-Newcomers-in-Nanomedicine-Overview-of-10-Years-of-Initiatory-Research.phphttp://www.heraldopenaccess.us/fulltext/General-Practice-&-Medical-Diagnosis/Biomimetic-Apatite-Based-Functional-Nanoparticles-as-Promising-Newcomers-in-Nanomedicine-Overview-of-10-Years-of-Initiatory-Research.php
HAL Id:hal-01195571
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Other partners > Aix-Marseille Université - AMU (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Ecole Nationale de l'Aviation Civile - ENAC (FRANCE)
Université de Toulouse > Ecole Nationale Supérieure de Formation de l'Enseignement Agricole - ENSFEA (FRANCE)
Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE)
Université de Toulouse > Ecole d'Ingénieurs de Purpan - EIP (FRANCE)
Université de Toulouse > Ecole nationale supérieure des Mines d'Albi-Carmaux - IMT Mines Albi (FRANCE)
Other partners > ICELLTIS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Institut National des Sciences Appliquées de Toulouse - INSA (FRANCE)
Université de Toulouse > Institut Supérieur de l'Aéronautique et de l'Espace - ISAE-SUPAERO (FRANCE)
Other partners > Université Nice Sophia Antipolis (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Université de Toulouse > Université Toulouse - Jean Jaurès - UT2J (FRANCE)
Université de Toulouse > Université Toulouse 1 Capitole - UT1 (FRANCE)
Université de Toulouse > Toulouse Business School - TBS (FRANCE)
Laboratory name:
Deposited On:08 Sep 2015 08:20

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